Holly, always trying to make a difference in the autism community, plans a simulated flight experience with American Airlines for families dealing with autism. Roman, finding it hard to say good-bye to Grams, plans a "Good-bye Gorgeous" week filled with fun activities while Holly struggles to plan a perfect anniversary date for Rodney.
Holly channels her inner momager to help Ryan prepare for her first L.A. performance, but her big night doesn't go as planned when Ryan's nerves get the best of her. After witnessing Dolores fall in the pool, Holly is on a mission to get her mother to wear a medical alert necklace. And, Holly sets out to learn if she's genetically predisposed to Parkinson's Disease.
Holly helps mentor a group of girls, by speaking on a panel and answering questions about bullying, school and making goals for the future, and is lucky enough to have the help of a few celebrity guests. Dolores asks Holly to help her look for a new home in Palm Springs, and in order to make the most of the trip, the entire family makes a vacation out of it. Rodney has father-daughter bonding time with Ryan.
While Holly starts construction on her newest project- RJ's Place, a pre-vocational training center for young people on the spectrum, Dolores is preparing for her new life in Palm Springs. Rodney finds himself with 2 new challenges, a juice cleanse and a golf lesson.
RJ decides to move into the guesthouse for the weekend to see what life is like on his own; Dolores heads to Palm Springs looking for a new adventure; Roman gets motivated to do some charity work.
While talking to Robinson about his upcoming school dance, Holly realizes RJ missed out on this quintessential social milestone and she sets out to give him the experience he deserves. Dolores continues her search for her long-lost half-sister and comes closer than ever before. And, Robinson enlists an unlikely family member to help him ask a girl to the dance.
Rodney tells Robinson he can redecorate his bedroom if he earns it, but Holly would rather gift it to him; Holly is asked to present her mother with a special award, but tensions mount when Dolores disagrees with her; Rodney plans a special surprise for Holly so the two can re-connect.
Despite landing her dream job in Vancouver, Holly’s overwhelming mom guilt prevents her from enjoying the experience; Rodney and the boys embark on adventures in Canada; the Peete’s offer hope and inspiration to families impacted by autism.
Holly heeds the call of mother and plans a spontaneous trip with Dolores to visit Ryan in New York City; the hunt for Dolores' long lost half-sister begins; Rodney's school of etiquette is in session.