When Hope Calls centers around sisters Lillian (Morgan Kohan) and Grace (Jocelyn Hudon) who open an orphanage in the 1916 Western town of Brookfield. As the two are caught between the traditions of cattle ranchers and the ambitions of a growing town, they strive to find romance and happiness while overcoming the challenges of helping the children in their care. Throughout their journey, they discover community, acceptance and love as they create the family they always longed to have. Viewers will recognize Kohan and Hudon who first appeared as their characters in the 2018 When Calls The Heart holiday movie, “The Great Christmas Blessing.”
The cast also includes R.J. Hatanaka as Gabriel, the Brookfield Mountie who catches Lillian's eye; Greg Hovanessian as Chuck, the ranch hand vying for Grace's heart; and Wendy Crewson as Tess, Chuck's mother and up until recent events, a longtime family friend of Lillian's.