When Hope Calls centers around sisters Lillian (Morgan Kohan) and Grace (Jocelyn Hudon) who open an orphanage in the 1916 Western town of Brookfield. As the two are caught between the traditions of cattle ranchers and the ambitions of a growing town, they strive to find romance and happiness while overcoming the challenges of helping the children in their care. Throughout their journey, they discover community, acceptance and love as they create the family they always longed to have. Viewers will recognize Kohan and Hudon who first appeared as their characters in the 2018 When Calls The Heart holiday movie, “The Great Christmas Blessing.”
Florence and Ned's wedding leads every couple in Hope Valley to evaluate their relationships. Rosemary realizes there is more happening in Hope Valley than everyone realizes and decides to get to the bottom of it.
Elizabeth, Carson and Faith deal with an outbreak of chickenpox, resulting in Rosemary falling ill. When Gowen is sued, Bill must pull together Hope Valley's first jury.