In the series pilot, Blanche announces that her latest boyfriend, Harry, has proposed marriage. Meanwhile, Dorothy must also contend with her mother, Sophia, who arrives after her retirement home, Shady Pines, burns down.
Rose has been dating Dr. Jonathan Newman and begins to think their relationship is leading to the altar. However she begins to have second thoughts especially since he's a midget.
Rose brings a man home and they spend the night together. However, in the morning she finds that he has passed away. Even worse, she later discovers he was married.
A week before an awards ceremony for the Volunteer of the Year, Blanche, Dorothy and Rose each come down with a nasty flu, which compounds their arguing over who will win the prestigious award.
Blanche is mortified after taking a pregnancy test which indicates she's pregnant. Then after visiting her doctor, she learns the truth, she's beginning menopause.
Blanche has won three tickets to see the opening of Burt Reynolds new movie and passes to the party held afterwards. However, on the evening of the opening, the hotel is raided and, the girls are mistaken as prostitutes.
Dorothy's old friend, Jean comes to Miami for a visit and Dorothy decides not to tell Blanche and Rose that Jean is a lesbian. Then, after spending time with Rose, Jean begins to fall for her.
Blanche's father comes to Miami and has an announcement, he's engaged to be married. Blanche is thrilled until she meets his fiance who happens to be younger than herself.
For Sophia's birthday, Dorothy flies in her sister, Angela from Sicily as a surprise. However, Dorothy's the one whose surprised when Sophia's reaction is that of disgust.
Sophia's sister, Angela arrives in Miami for a visit and decides to move there but while she's looking for an apartment Dorothy invites her to stay with the girls.
The girls invite their new neighbors over for dinner but later, after they leave, two police detectives arrive with some unsettling news, the girls' new neighbors are really dealers in stolen gems.
Sophia befriends an old man on the boardwalk whom she becomes quick friends with. However, his strange behavior signals that he has a medical condition, Alzheimer's disease.
Rose becomes concerned about nuclear war. This prompts her to write letters to Gorbachev and Reagan. She's stunned when she gets a response and learns that Gorbechev would like to meet her.
Sophia's brother, Angelo, a priest, comes to Miami for a visit and he doesn't know Dorothy and Stan are divorced. So, Sophia convinces Dorothy and Stan to pretend to be married.
The death of a close friend, Esther Weinstock, brings Sophia face to face with Esther's husband a man whom she vowed never to speak to again. However, when Dorothy prompts them to make up they get a little too close.
Rose discovers that she may be carrying the HIV virus after learning the blood they used in her gallbladder operation may have contained HIV antibodies.
An FBI agent investigates the girls' life's for a possible visit from President Bush. This leads the girls to reminisce about times they have spent together.
Blanche's brother Clayton, visits Miami with a surprise, he has found the right person to make a commitment to, but Blanche still can't get over Clayton's sexual orientation.
Blanche needs someone to entertain her visiting Uncle Lucas. She persuades Dorothy into going out with him and the two later come up with a scheme to get revenge on Blanche.
As Dorothy's wedding day approaches, everyone is making preparations. In the end, Sophia and Rose decide to stay with Blanche and Dorothy says a tearful goodbye.
When Gus needs help, Nancy begins to wonder if Clayton is ready to support her. Doubts also start to crowd Mae's mind about Clayton's presence in town. Stars Schuyler Fisk, Genevieve Angelson, Lea Thompson, and Wendie Malick.
Mystery Island success raises plans of expansion, and the Island team meets their Mystery Mountain counterparts for a friendly murder game, but the fun ends with a murder in plain sight. Stars Elizabeth Henstridge, Charlie Weber.
Danny finds the courage to admit his romantic feelings for his best friend, when he is asked to be the best man at his wedding in Greece. Stars Jonathan Bennett, Alexander Lincoln, Tyler Hynes, BJ Britt.
